Apolipoprotein AI and the molecular variant apoA-IMilano: Evaluation of the antiatherogenic effects in knock-in mouse model
C Parolini, G Chiesa, E Gong, S Caligari, MM Cortese… - Atherosclerosis, 2005 - Elsevier
No evidence of premature vascular disease is found in apolipoprotein A-IMilano (apoA-IM)
human carriers, despite very low high density lipoprotein (HDL) cholesterol levels. Whether
apoA-IM may impart a “gain of function” in atherosclerosis protection compared to wild-type
apoA-I is hotly debated. To address this question, knock-in mice expressing human apoA-I
or apoA-IM were crossed with atherosclerosis-susceptible mice expressing the human
apoB/A-II transgene (hB/A-II/A-IHu/Hu and hB/A-II/A-IMHu/Hu). On a chow diet, hB/A-II/A …
human carriers, despite very low high density lipoprotein (HDL) cholesterol levels. Whether
apoA-IM may impart a “gain of function” in atherosclerosis protection compared to wild-type
apoA-I is hotly debated. To address this question, knock-in mice expressing human apoA-I
or apoA-IM were crossed with atherosclerosis-susceptible mice expressing the human
apoB/A-II transgene (hB/A-II/A-IHu/Hu and hB/A-II/A-IMHu/Hu). On a chow diet, hB/A-II/A …