[HTML][HTML] Extramedullary erythropoiesis in the adult liver requires BMP-4/Smad5–dependent signaling
LE Lenox, L Shi, S Hegde, RF Paulson - Experimental hematology, 2009 - Elsevier
OBJECTIVE: In mice, homeostatic erythropoiesis occurs primarily in the bone marrow.
However, in response to acute anemia, bone morphogenetic proteins 4 (BMP-4)−
dependent stress erythropoiesis occurs in the adult spleen. BMP-4 can also regulate stress
erythropoiesis in the fetal liver. In humans, erythropoiesis occurs in the bone marrow.
However, in certain pathological conditions, extramedullary erythropoiesis is observed,
where it can occur in several organs, including the liver. Given these observations, we …
However, in response to acute anemia, bone morphogenetic proteins 4 (BMP-4)−
dependent stress erythropoiesis occurs in the adult spleen. BMP-4 can also regulate stress
erythropoiesis in the fetal liver. In humans, erythropoiesis occurs in the bone marrow.
However, in certain pathological conditions, extramedullary erythropoiesis is observed,
where it can occur in several organs, including the liver. Given these observations, we …