[HTML][HTML] Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin
RM Forteza, SM Casalino-Matsuda, NS Falcon… - Journal of Biological …, 2012 - ASBMB
Cigarette smoke (CigS) exposure is associated with increased bronchial epithelial
permeability and impaired barrier function. Primary cultures of normal human bronchial
epithelial cells exposed to CigS exhibit decreased E-cadherin expression and reduced
transepithelial electrical resistance. These effects were mediated by hyaluronan (HA)
because inhibition of its synthesis with 4-methylumbelliferone prevented these effects, and
exposure to HA fragments of< 70 kDa mimicked these effects. We show that the HA receptor …
permeability and impaired barrier function. Primary cultures of normal human bronchial
epithelial cells exposed to CigS exhibit decreased E-cadherin expression and reduced
transepithelial electrical resistance. These effects were mediated by hyaluronan (HA)
because inhibition of its synthesis with 4-methylumbelliferone prevented these effects, and
exposure to HA fragments of< 70 kDa mimicked these effects. We show that the HA receptor …