[HTML][HTML] Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol [S]
X Zhu, JS Owen, MD Wilson, H Li, GL Griffiths… - Journal of lipid …, 2010 - ASBMB
We previously showed that macrophages from macrophage-specific ATP-binding cassette
transporter A1 (ABCA1) knockout (Abca1-M/-M) mice had an enhanced proinflammatory
response to the Toll-like receptor (TLR) 4 agonist, lipopolysaccharide (LPS), compared with
wild-type (WT) mice. In the present study, we demonstrate a direct association between free
cholesterol (FC), lipid raft content, and hyper-responsiveness of macrophages to LPS in WT
mice. Abca1-M/-M macrophages were also hyper-responsive to specific agonists to TLR2 …
transporter A1 (ABCA1) knockout (Abca1-M/-M) mice had an enhanced proinflammatory
response to the Toll-like receptor (TLR) 4 agonist, lipopolysaccharide (LPS), compared with
wild-type (WT) mice. In the present study, we demonstrate a direct association between free
cholesterol (FC), lipid raft content, and hyper-responsiveness of macrophages to LPS in WT
mice. Abca1-M/-M macrophages were also hyper-responsive to specific agonists to TLR2 …