Antigen of “serum sickness” type of heterophile antibodies in human sera: identification as gangliosides with N-glycolylneuraminic acid
H Higashi, M Naiki, S Matuo, K Ōkouchi - Biochemical and biophysical …, 1977 - Elsevier
H Higashi, M Naiki, S Matuo, K Ōkouchi
Biochemical and biophysical research communications, 1977•ElsevierAntigen of “serum-sickness” type of heterophile antibodies in pathologic human sera was
purified from equine and bovine erythrocyte stroma. The chemical nature of this antigen was
glycosphingolipids with N-glycolylneuraminic acid. The antigen of equine erythrocytes was
identified as hematoside with N-glycolylneuraminic acid, GlNeu (α, 2–3) Gal (β, 1–4) Glc (β,
1-1) ceramide and the antigen of bovine erythrocytes was N-glycolylneuraminyl-
paragloboside, GlNeu (α, 2–3) Gal (β, 1–4) GlcNAc (β, 1–3) Gal (β, 1–4) Glc (β, 1-1) …
purified from equine and bovine erythrocyte stroma. The chemical nature of this antigen was
glycosphingolipids with N-glycolylneuraminic acid. The antigen of equine erythrocytes was
identified as hematoside with N-glycolylneuraminic acid, GlNeu (α, 2–3) Gal (β, 1–4) Glc (β,
1-1) ceramide and the antigen of bovine erythrocytes was N-glycolylneuraminyl-
paragloboside, GlNeu (α, 2–3) Gal (β, 1–4) GlcNAc (β, 1–3) Gal (β, 1–4) Glc (β, 1-1) …
Abstract
Antigen of “serum-sickness” type of heterophile antibodies in pathologic human sera was purified from equine and bovine erythrocyte stroma. The chemical nature of this antigen was glycosphingolipids with N-glycolylneuraminic acid. The antigen of equine erythrocytes was identified as hematoside with N-glycolylneuraminic acid, GlNeu(α, 2–3)Gal(β, 1–4)Glc(β,1-1) ceramide and the antigen of bovine erythrocytes was N-glycolylneuraminyl-paragloboside, GlNeu (α,2–3)Gal(β,1–4)GlcNAc(β,1–3)Gal(β,1–4)Glc(β,1-1) ceramide. The results indicate that “serum-sickness” antibodies react with a common disaccharide moiety of non-reducing end of the both glycosphingolipids.
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