[HTML][HTML] The Molecular Basis for the Absence ofN-Glycolylneuraminic Acid in Humans
A Irie, S Koyama, Y Kozutsumi, T Kawasaki… - Journal of Biological …, 1998 - ASBMB
N-Glycolylneuraminic acid (NeuGc) is abundantly expressed in most mammals, but it is not
detectable in humans. The expression of NeuGc is controlled by cytidine monophospho-N-
acetylneuraminic acid (CMP-NeuAc) hydroxylase activity. We previously cloned a cDNA for
mouse CMP-NeuAc hydroxylase and found that the human genome contains a homologue.
We report here the molecular basis for the absence of NeuGc in humans. We cloned a cDNA
for human CMP-NeuAc hydroxylase from a HeLa cell cDNA library. The cDNA encodes a …
detectable in humans. The expression of NeuGc is controlled by cytidine monophospho-N-
acetylneuraminic acid (CMP-NeuAc) hydroxylase activity. We previously cloned a cDNA for
mouse CMP-NeuAc hydroxylase and found that the human genome contains a homologue.
We report here the molecular basis for the absence of NeuGc in humans. We cloned a cDNA
for human CMP-NeuAc hydroxylase from a HeLa cell cDNA library. The cDNA encodes a …