Sepsis: a new hypothesis for pathogenesis of the disease process
RC Bone, CJ Grodzin, RA Balk - Chest, 1997 - journal.chestnet.org
The incidence of sepsis continues to increase. Sepsis and its sequelae are the leading
causes of death in medical and surgical ICUs. 1• 2 According to the Centers for Disease
Control and Prevention, the incidence of sepsis continues to increase and is now the third
leading cause of infectious death (Fig 1). Sepsis and its sequelae represent progressive
stages of the same illness-a systemic response to infection mediated via macrophage-
derived cytokines that target end-organ receptors in response to injury or infection. Much …
causes of death in medical and surgical ICUs. 1• 2 According to the Centers for Disease
Control and Prevention, the incidence of sepsis continues to increase and is now the third
leading cause of infectious death (Fig 1). Sepsis and its sequelae represent progressive
stages of the same illness-a systemic response to infection mediated via macrophage-
derived cytokines that target end-organ receptors in response to injury or infection. Much …