The importance of CELF control: molecular and biological roles of the CUG‐BP, Elav‐like family of RNA‐binding proteins
T Dasgupta, AN Ladd - Wiley Interdisciplinary Reviews: RNA, 2012 - Wiley Online Library
T Dasgupta, AN Ladd
Wiley Interdisciplinary Reviews: RNA, 2012•Wiley Online LibraryRNA processing is important for generating protein diversity and modulating levels of protein
expression. The CUG‐BP, Elav‐like family (CELF) of RNA‐binding proteins regulate several
steps of RNA processing in the nucleus and cytoplasm, including pre‐mRNA alternative
splicing, C to U RNA editing, deadenylation, mRNA decay, and translation. In vivo, CELF
proteins have been shown to play roles in gametogenesis and early embryonic
development, heart and skeletal muscle function, and neurosynaptic transmission …
expression. The CUG‐BP, Elav‐like family (CELF) of RNA‐binding proteins regulate several
steps of RNA processing in the nucleus and cytoplasm, including pre‐mRNA alternative
splicing, C to U RNA editing, deadenylation, mRNA decay, and translation. In vivo, CELF
proteins have been shown to play roles in gametogenesis and early embryonic
development, heart and skeletal muscle function, and neurosynaptic transmission …
Abstract
RNA processing is important for generating protein diversity and modulating levels of protein expression. The CUG‐BP, Elav‐like family (CELF) of RNA‐binding proteins regulate several steps of RNA processing in the nucleus and cytoplasm, including pre‐mRNA alternative splicing, C to U RNA editing, deadenylation, mRNA decay, and translation. In vivo, CELF proteins have been shown to play roles in gametogenesis and early embryonic development, heart and skeletal muscle function, and neurosynaptic transmission. Dysregulation of CELF‐mediated programs has been implicated in the pathogenesis of human diseases affecting the heart, skeletal muscles, and nervous system. WIREs RNA 2012, 3:104–121. doi: 10.1002/wrna.107
This article is categorized under:
- Translation > Translation Regulation
- RNA Processing > Splicing Regulation/Alternative Splicing
- RNA Turnover and Surveillance > Regulation of RNA Stability
- Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs
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