[HTML][HTML] Development of type 1 diabetes despite severe hereditary B-cell deficiency
S Martin, D Wolf-Eichbaum, G Duinkerken… - … England Journal of …, 2001 - Mass Medical Soc
S Martin, D Wolf-Eichbaum, G Duinkerken, WA Scherbaum, H Kolb, JG Noordzij, BO Roep
New England Journal of Medicine, 2001•Mass Medical SocType 1 diabetes results from an immune-mediated destruction of pancreatic beta cells. The
disease can be transmitted by bone marrow transplantation in humans1 and animals. 2, 3
Furthermore, T cells that are reactive to several islet autoantigens have been identified in
both mice and humans. 4, 5 Although it is generally accepted that T cells have a role during
the disease process, the possible role of B cells and autoantibodies in type 1 diabetes in
humans has not been fully resolved. When they are activated, B cells can produce …
disease can be transmitted by bone marrow transplantation in humans1 and animals. 2, 3
Furthermore, T cells that are reactive to several islet autoantigens have been identified in
both mice and humans. 4, 5 Although it is generally accepted that T cells have a role during
the disease process, the possible role of B cells and autoantibodies in type 1 diabetes in
humans has not been fully resolved. When they are activated, B cells can produce …
Type 1 diabetes results from an immune-mediated destruction of pancreatic beta cells. The disease can be transmitted by bone marrow transplantation in humans1 and animals.2,3 Furthermore, T cells that are reactive to several islet autoantigens have been identified in both mice and humans.4,5 Although it is generally accepted that T cells have a role during the disease process, the possible role of B cells and autoantibodies in type 1 diabetes in humans has not been fully resolved. When they are activated, B cells can produce autoantibodies to pancreatic beta-cell antigens — such as glutamic acid decarboxylase 65 (GAD65), . . .
The New England Journal Of Medicine