Arthrogryposis multiplex congenita (AMC) is a heterogeneous group of congenital
contracture syndromes, some of which are hereditary. To date, four genetic loci associated
with autosomal recessive arthrogryposis syndromes have been identified using the powerful
tools of genome-wide linkage analysis and homozygosity mapping. In the consanguineous
inbred Bedouin population in southern Israel there is an unusually high incidence of
hereditary arthrogryposis. We hypothesized the high incidence of this phenotype in this …