Towards a standardization of the murine tail bleeding model

TK Greene, A Schiviz, W Hoellriegl, M Poncz… - Journal of Thrombosis …, 2010 - jthjournal.org
Standardizing the risk of bleeding remains an important clinical goal, and ideally should take
into account coagulation factors, platelet functionality, and vascular integrity issues. One
such test to which a great deal of energy has been devoted for standardization has been the
human template bleeding time [1]. This test now routinely involves using a precise forearm
incision under specific blood pressure conditions, but in spite of such measures, this test is
not as good as a careful history in predicting risk of bleeding with surgery [2, 3]. When …