Towards a standardization of the murine tail bleeding model
Standardizing the risk of bleeding remains an important clinical goal, and ideally should take
into account coagulation factors, platelet functionality, and vascular integrity issues. One
such test to which a great deal of energy has been devoted for standardization has been the
human template bleeding time [1]. This test now routinely involves using a precise forearm
incision under specific blood pressure conditions, but in spite of such measures, this test is
not as good as a careful history in predicting risk of bleeding with surgery [2, 3]. When …
into account coagulation factors, platelet functionality, and vascular integrity issues. One
such test to which a great deal of energy has been devoted for standardization has been the
human template bleeding time [1]. This test now routinely involves using a precise forearm
incision under specific blood pressure conditions, but in spite of such measures, this test is
not as good as a careful history in predicting risk of bleeding with surgery [2, 3]. When …