Increased epithelial gaps in the small intestine are predictive of hospitalization and surgery in patients with inflammatory bowel disease
JF Turcotte, K Wong, SJ Mah… - Clinical and …, 2012 - journals.lww.com
OBJECTIVES: Epithelial gaps resulting from intestinal cell extrusions can be visualized with
confocal laser endomicroscopy (CLE) during colonoscopy and increased in normal-
appearing terminal ileum of inflammatory bowel disease (IBD) patients. Cell-shedding
events on CLE were found to be predictive of disease relapse. The aim of this study was to
assess the prognostic value of epithelial gap densities for major clinical events
(hospitalization or surgery) in follow-up. METHODS: We prospectively followed IBD patients …
confocal laser endomicroscopy (CLE) during colonoscopy and increased in normal-
appearing terminal ileum of inflammatory bowel disease (IBD) patients. Cell-shedding
events on CLE were found to be predictive of disease relapse. The aim of this study was to
assess the prognostic value of epithelial gap densities for major clinical events
(hospitalization or surgery) in follow-up. METHODS: We prospectively followed IBD patients …