[HTML][HTML] MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7 receptor by activation of instability sites at the 3 …
L Zhou, X Qi, JA Potashkin, FW Abdul-Karim… - Journal of Biological …, 2008 - ASBMB
The P2X 7 receptor regulates cell growth through mediation of apoptosis. P2X 7 levels are
lower in cancer epithelial cells than in normal cells, and previous studies showed that
expression of P2X 7 was regulated post-transcriptionally. The objective of the study was to
understand regulation of P2X 7 mRNA stability. Overexpression of a reporter containing the
full-length human P2X 7 3′-untranslated region (3′-UTR) or reporters containing parts of
the 3′-UTR-P2X 7 were associated with increased abundance of the construct in normal …
lower in cancer epithelial cells than in normal cells, and previous studies showed that
expression of P2X 7 was regulated post-transcriptionally. The objective of the study was to
understand regulation of P2X 7 mRNA stability. Overexpression of a reporter containing the
full-length human P2X 7 3′-untranslated region (3′-UTR) or reporters containing parts of
the 3′-UTR-P2X 7 were associated with increased abundance of the construct in normal …