Cellular signaling by fibroblast growth factor receptors

VP Eswarakumar, I Lax, J Schlessinger - Cytokine & growth factor reviews, 2005 - Elsevier
The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their
cellular responses by binding to and activating the different isoforms encoded by the four
receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. Unlike
other growth factors, FGFs act in concert with heparin or heparan sulfate proteoglycan
(HSPG) to activate FGFRs and to induce the pleiotropic responses that lead to the variety of
cellular responses induced by this large family of growth factors. A variety of human skeletal …