Pathologic study of a disease provides insights into the precise mechanisms and targets of
damage and may provide insights into new therapies. The main targets in diabetic
neuropathy are myelinated and unmyelinated fibers as dysfunction and damage to them
explains the symptoms of painful neuropathy and the major end points of foot ulceration and
amputation as well as mortality. Demyelination and axonal degeneration are established
hallmarks of the pathology of human diabetic neuropathy and were derived from pioneering …