[HTML][HTML] An open-label, single-dose, crossover study of the pharmacokinetics and metabolism of two oral formulations of 1-octanol in patients with essential tremor
FB Nahab, L Wittevrongel, D Ippolito, C Toro… - …, 2011 - Elsevier
Existing therapeutic options for management of essential tremor are frequently limited by
poor efficacy and adverse effects. Likely the most potent tremor suppressant used is ethanol,
although its use is prohibitive due to a brief therapeutic window, and the obvious
implications of excessive alcohol use. Longer-chain alcohols have been shown to suppress
tremor in harmaline animal models, and appear to be safe and well tolerated in 2 prior
studies in humans. Here we report on the findings of a phase I/II study of 1-octanol designed …
poor efficacy and adverse effects. Likely the most potent tremor suppressant used is ethanol,
although its use is prohibitive due to a brief therapeutic window, and the obvious
implications of excessive alcohol use. Longer-chain alcohols have been shown to suppress
tremor in harmaline animal models, and appear to be safe and well tolerated in 2 prior
studies in humans. Here we report on the findings of a phase I/II study of 1-octanol designed …