Effect of varying doses of a monovalent H7N9 influenza vaccine with and without AS03 and MF59 adjuvants on immune response: a randomized clinical trial
LA Jackson, JD Campbell, SE Frey, KM Edwards… - Jama, 2015 - jamanetwork.com
Importance Human infections with the avian influenza A (H7N9) virus were first reported in
China in 2013 and continue to occur. Hemagglutinin H7 administered alone is a poor
immunogen necessitating evaluation of adjuvanted H7N9 vaccines. Objective To evaluate
the immunogenicity and safety of an inactivated H7N9 vaccine with and without AS03
adjuvant, as well as mixed vaccine schedules that included sequential administration of
AS03-and MF59-containing formulations and of adjuvanted and unadjuvanted formulations …
China in 2013 and continue to occur. Hemagglutinin H7 administered alone is a poor
immunogen necessitating evaluation of adjuvanted H7N9 vaccines. Objective To evaluate
the immunogenicity and safety of an inactivated H7N9 vaccine with and without AS03
adjuvant, as well as mixed vaccine schedules that included sequential administration of
AS03-and MF59-containing formulations and of adjuvanted and unadjuvanted formulations …