Frequent co‐expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement
T Imamura, A Morimoto, M Takanashi… - British journal of …, 2002 - Wiley Online Library
T Imamura, A Morimoto, M Takanashi, S Hibi, T Sugimoto, E Ishii, S Imashuku
British journal of haematology, 2002•Wiley Online LibraryWe studied the expression of HoxA9 and Meis1 by reverse transcriptase‐polymerase chain
reaction analysis in leukaemic cells from cases of infant acute lymphoblastic leukaemia
(ALL, n= 27) and childhood ALL (n= 29). These two genes were co‐expressed significantly
more frequently in infant ALL than in childhood ALL (19/27 vs0/29 cases, P< 0· 001) and
were highly associated with MLL gene rearrangement in infant ALL cases (P< 0· 001).
These findings indicate that the HoxA9 and Meis1 genes are closely associated with MLL …
reaction analysis in leukaemic cells from cases of infant acute lymphoblastic leukaemia
(ALL, n= 27) and childhood ALL (n= 29). These two genes were co‐expressed significantly
more frequently in infant ALL than in childhood ALL (19/27 vs0/29 cases, P< 0· 001) and
were highly associated with MLL gene rearrangement in infant ALL cases (P< 0· 001).
These findings indicate that the HoxA9 and Meis1 genes are closely associated with MLL …
Summary
We studied the expression of HoxA9 and Meis1 by reverse transcriptase‐polymerase chain reaction analysis in leukaemic cells from cases of infant acute lymphoblastic leukaemia (ALL, n = 27) and childhood ALL (n = 29). These two genes were co‐expressed significantly more frequently in infant ALL than in childhood ALL (19/27 vs0/29 cases, P < 0·001) and were highly associated with MLL gene rearrangement in infant ALL cases (P < 0·001). These findings indicate that the HoxA9 and Meis1 genes are closely associated with MLL gene rearrangement in the development of infant ALL, which represents a distinct entity of childhood ALL.
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