[HTML][HTML] Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein …
R Suvasini, B Shruti, B Thota, SV Shinde… - Journal of Biological …, 2011 - ASBMB
Glioblastoma is the most common and malignant form of primary astrocytoma. Upon
investigation of the insulin-like growth factor (IGF) pathway, we found the IGF2BP3/IMP3
transcript and protein to be up-regulated in GBMs but not in lower grade astrocytomas (p<
0.0001). IMP3 is an RNA binding protein known to bind to the 5′-untranslated region of IGF-
2 mRNA, thereby activating its translation. Overexpression-and knockdown-based studies
establish a role for IMP3 in promoting proliferation, anchorage-independent growth …
investigation of the insulin-like growth factor (IGF) pathway, we found the IGF2BP3/IMP3
transcript and protein to be up-regulated in GBMs but not in lower grade astrocytomas (p<
0.0001). IMP3 is an RNA binding protein known to bind to the 5′-untranslated region of IGF-
2 mRNA, thereby activating its translation. Overexpression-and knockdown-based studies
establish a role for IMP3 in promoting proliferation, anchorage-independent growth …