[HTML][HTML] Activation of AMP-activated protein kinase α1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin
Accumulating evidence suggests that AMP-activated protein kinase (AMPK) activation exerts
anti-apoptotic effects in multiple types of cells. However, the underlying mechanisms remain
poorly defined. The aim of the present study was to determine how AMPK suppresses
apoptosis in endothelial cells exposed to hypoxia and glucose deprivation (OGD). AMPK
activity, NF-κB activation, and endothelial cell apoptosis were assayed in cultured
endothelial cells and mouse common carotid artery with or without OGD treatment. OGD …
anti-apoptotic effects in multiple types of cells. However, the underlying mechanisms remain
poorly defined. The aim of the present study was to determine how AMPK suppresses
apoptosis in endothelial cells exposed to hypoxia and glucose deprivation (OGD). AMPK
activity, NF-κB activation, and endothelial cell apoptosis were assayed in cultured
endothelial cells and mouse common carotid artery with or without OGD treatment. OGD …