[HTML][HTML] Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth
MA Ozog, G Modha, J Church, R Reilly… - Journal of biological …, 2008 - ASBMB
Attempts to promote neuronal survival and repair with ciliary neurotrophic factor (CNTF)
have met with limited success. The variability of results obtained with CNTF may, in part,
reflect the fact that some of the biological actions of the cytokine are mediated by a complex
formed between CNTF and its specific receptor, CNTFRα, which exists in both membrane-
bound and soluble forms. In this study, we compared the actions of CNTF alone and CNTF
complexed with soluble CNTFRα (hereafter termed" Complex") on neuronal survival and …
have met with limited success. The variability of results obtained with CNTF may, in part,
reflect the fact that some of the biological actions of the cytokine are mediated by a complex
formed between CNTF and its specific receptor, CNTFRα, which exists in both membrane-
bound and soluble forms. In this study, we compared the actions of CNTF alone and CNTF
complexed with soluble CNTFRα (hereafter termed" Complex") on neuronal survival and …