Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution, and regulation by glucocorticoids, cyclic AMP, and phorbol ester.
H Higuchi, HYT Yang, SL Sabol - Journal of Biological Chemistry, 1988 - ASBMB
Rat brain neuropeptide Y precursor (prepro-NPY) cDNA clones were isolated and
sequenced in order to study regulation of the prepro-NPY gene. Rat prepro-NPY (98 amino
acid residues) contains a 36-residue NPY sequence, followed by a proteolysis/amidation
site Gly-Lys-Arg, followed by a 30-residue COOH-terminal sequence. The strong
evolutionary conservation of rat and human sequences of NPY (100%) and COOH-terminal
peptide (93%) suggests that both peptides have important biological functions. In the rat …
sequenced in order to study regulation of the prepro-NPY gene. Rat prepro-NPY (98 amino
acid residues) contains a 36-residue NPY sequence, followed by a proteolysis/amidation
site Gly-Lys-Arg, followed by a 30-residue COOH-terminal sequence. The strong
evolutionary conservation of rat and human sequences of NPY (100%) and COOH-terminal
peptide (93%) suggests that both peptides have important biological functions. In the rat …