[HTML][HTML] Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2
TE Danciu, S Chupreta, O Cruz, JE Fox… - Journal of Biological …, 2012 - ASBMB
FOXC1 and FOXC2 are forkhead transcription factors that play essential roles during
development and physiology. Despite their critical role, the mechanisms that regulate the
function of these factors remain poorly understood. We have identified conserved motifs
within a previously defined N-terminal negative regulatory region of FOXC1/C2 that
conforms to the definition of synergy control or SC motifs. Because such motifs inhibit the
activity of transcription factors by serving as sites of post-translational modification by small …
development and physiology. Despite their critical role, the mechanisms that regulate the
function of these factors remain poorly understood. We have identified conserved motifs
within a previously defined N-terminal negative regulatory region of FOXC1/C2 that
conforms to the definition of synergy control or SC motifs. Because such motifs inhibit the
activity of transcription factors by serving as sites of post-translational modification by small …