[HTML][HTML] Proteomic and Functional Analyses Reveal the Role of Chromatin Reader SFMBT1 in Regulating Epigenetic Silencing and the Myogenic Gene Program*[S]
Background: SFMBT1 is a poorly characterized chromatin reader. Results: SFMBT1 is
associated with multiple transcriptional corepressor complexes and required for MyoD-
mediated transcriptional silencing. Conclusion: Novel mechanisms of SFMBT1-mediated
transcription repression and its regulation of myogenesis are identified. Significance: Our
findings contribute to the understanding of how histone modification language is interpreted
to regulate gene expression and biological processes. SFMBT1 belongs to the malignant …
associated with multiple transcriptional corepressor complexes and required for MyoD-
mediated transcriptional silencing. Conclusion: Novel mechanisms of SFMBT1-mediated
transcription repression and its regulation of myogenesis are identified. Significance: Our
findings contribute to the understanding of how histone modification language is interpreted
to regulate gene expression and biological processes. SFMBT1 belongs to the malignant …