Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells
D Liu, L Song, VS Brawley, N Robison, J Wei, X Gao… - Clinical …, 2013 - Elsevier
Medulloblastoma (MB) is the most common malignant brain tumor of childhood. Current
therapies are toxic and not always curative that necessitates development of targeted
immunotherapy. However, little is known about immunobiology of this tumor. In this study,
we show that MB cells in 9 of 20 primary tumors express CD1d, an antigen-presenting
molecule for Natural Killer T cells (NKTs). Quantitative RT-PCR analysis of 61 primary
tumors revealed an elevated level of CD1d mRNA expression in a molecular subgroup …
therapies are toxic and not always curative that necessitates development of targeted
immunotherapy. However, little is known about immunobiology of this tumor. In this study,
we show that MB cells in 9 of 20 primary tumors express CD1d, an antigen-presenting
molecule for Natural Killer T cells (NKTs). Quantitative RT-PCR analysis of 61 primary
tumors revealed an elevated level of CD1d mRNA expression in a molecular subgroup …