[HTML][HTML] Synthesis of New 2,5-Di-substituted 1,3,4-Oxadiazoles Bearing 2,6-Di-tert-butylphenol Moieties and Evaluation of Their Antioxidant Activity
molecules, 2014•mdpi.com
Eleven new 2, 6-di-tert-butyl-4-(5-aryl-1, 3, 4-oxadiazol-2-yl) phenols 5a–k were synthesized
by reacting aryl hydrazides with 3, 5-di-tert butyl 4-hydroxybenzoic acid in the presence of
phosphorus oxychloride. The resulting compounds were characterized based on their IR, 1H-
NMR, 13C-NMR, and HRMS data. 2, 2-Diphenyl-1-picrylhydrazide (DPPH) and ferric
reducing antioxidant power (FRAP) assays were used to test the antioxidant properties of
the compounds. Compounds 5f and 5j exhibited significant free-radical scavenging ability in …
by reacting aryl hydrazides with 3, 5-di-tert butyl 4-hydroxybenzoic acid in the presence of
phosphorus oxychloride. The resulting compounds were characterized based on their IR, 1H-
NMR, 13C-NMR, and HRMS data. 2, 2-Diphenyl-1-picrylhydrazide (DPPH) and ferric
reducing antioxidant power (FRAP) assays were used to test the antioxidant properties of
the compounds. Compounds 5f and 5j exhibited significant free-radical scavenging ability in …
Eleven new 2,6-di-tert-butyl-4-(5-aryl-1,3,4-oxadiazol-2-yl)phenols 5a–k were synthesized by reacting aryl hydrazides with 3,5-di-tert butyl 4-hydroxybenzoic acid in the presence of phosphorus oxychloride. The resulting compounds were characterized based on their IR, 1H-NMR, 13C-NMR, and HRMS data. 2,2-Diphenyl-1-picrylhydrazide (DPPH) and ferric reducing antioxidant power (FRAP) assays were used to test the antioxidant properties of the compounds. Compounds 5f and 5j exhibited significant free-radical scavenging ability in both assays.
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