Regulation of immunity and oncogenesis by the IRF transcription factor family
D Savitsky, T Tamura, H Yanai, T Taniguchi - Cancer immunology …, 2010 - Springer
D Savitsky, T Tamura, H Yanai, T Taniguchi
Cancer immunology, immunotherapy, 2010•SpringerNine interferon regulatory factors (IRFs) compose a family of transcription factors in
mammals. Although this family was originally identified in the context of the type I interferon
system, subsequent studies have revealed much broader functions performed by IRF
members in host defense. In this review, we provide an update on the current knowledge of
their roles in immune responses, immune cell development, and regulation of oncogenesis.
mammals. Although this family was originally identified in the context of the type I interferon
system, subsequent studies have revealed much broader functions performed by IRF
members in host defense. In this review, we provide an update on the current knowledge of
their roles in immune responses, immune cell development, and regulation of oncogenesis.
Abstract
Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis.
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