Can statins prevent pregnancy complications?

G Girardi - Journal of reproductive immunology, 2014 - Elsevier
Statins are potent inhibitors of cholesterol biosynthesis. The beneficial effects of the statins in
preventing cardiovascular diseases are not entirely due to cholesterol reduction. Numerous
studies suggest that the benefits observed with statins may be mediated by pleiotropic
effects that are cholesterol-independent. There is now compelling evidence that statin
therapy may diminish inflammation and oxidative stress, increase angiogenesis, inhibit the
coagulation cascade and protect the endothelium. Several animal studies demonstrated that …