[HTML][HTML] Increased D-type cyclin expression together with decreased cdc2 activity confers megakaryocytic differentiation of a human thrombopoietin-dependent …
I Matsumura, H Tanaka, A Kawasaki, J Odajima… - Journal of Biological …, 2000 - ASBMB
At the late phase of megakaryocytopoiesis, megakaryocytes undergo endomitosis, which is
characterized by DNA replication without cell division. Although a number of cell cycle
regulatory molecules have been identified, the precise roles of these molecules in
megakaryocytic endomitosis are largely unknown. In a human interleukin-3-dependent cell
line transfected with the thrombopoietin (TPO) receptor c-mpl (F-36P-mpl), either treatment
with TPO or the overexpression of activated ras (Ha-Ras G12V) induced megakaryocytic …
characterized by DNA replication without cell division. Although a number of cell cycle
regulatory molecules have been identified, the precise roles of these molecules in
megakaryocytic endomitosis are largely unknown. In a human interleukin-3-dependent cell
line transfected with the thrombopoietin (TPO) receptor c-mpl (F-36P-mpl), either treatment
with TPO or the overexpression of activated ras (Ha-Ras G12V) induced megakaryocytic …
