Comparative analysis of dendritic cell density and total number in commonly transplanted organs: morphometric estimation in normal mice
RJ Steptoe, RK Patel, VM Subbotin, AW Thomson - Transplant immunology, 2000 - Elsevier
Dendritic cells (DC) are considered to be the major cell type responsible for induction of
primary immune responses. While they have been shown to play a critical role in eliciting
allosensitization via the direct pathway, there is evidence that maturational and/or
activational heterogeneity between DC in different donor organs may be crucial to allograft
outcome. Despite such an important perceived role for DC, no accurate estimates of their
number in commonly transplanted organs have been reported. Therefore, leukocytes and …
primary immune responses. While they have been shown to play a critical role in eliciting
allosensitization via the direct pathway, there is evidence that maturational and/or
activational heterogeneity between DC in different donor organs may be crucial to allograft
outcome. Despite such an important perceived role for DC, no accurate estimates of their
number in commonly transplanted organs have been reported. Therefore, leukocytes and …