[HTML][HTML] Preferential priming of alloreactive T cells with indirect reactivity
TV Brennan, A Jaigirdar, V Hoang, T Hayden… - American Journal of …, 2009 - Elsevier
The relative contributions of the direct and indirect pathways in alloimmune responses have
not been fully elucidated. We report a novel murine TCR transgenic system that can
simultaneously track the CD4-direct (CD4-d), CD4-indirect (CD4-i) and CD8-direct (CD8-d)
pathways after transplantation. Using this system, we have observed a profoundly greater
proliferation of CD4-i T cells relative to CD4-d and CD8-d T cells after transplantation.
Furthermore, a much larger proportion of CD4-i T cells attain an effector phenotype. We also …
not been fully elucidated. We report a novel murine TCR transgenic system that can
simultaneously track the CD4-direct (CD4-d), CD4-indirect (CD4-i) and CD8-direct (CD8-d)
pathways after transplantation. Using this system, we have observed a profoundly greater
proliferation of CD4-i T cells relative to CD4-d and CD8-d T cells after transplantation.
Furthermore, a much larger proportion of CD4-i T cells attain an effector phenotype. We also …