[PDF][PDF] The two faces of NF-κB signaling in cancer development and therapy
Constitutive activation of NF-κB signaling can promote oncogenesis, providing a rationale
for anticancer strategies that inhibit NF-κB signaling. Two recent publications in Genes &
Development provide evidence that, in contexts where prosurvival signals derive from other
oncogenes, NF-κB activity instead enhances sensitivity to cytotoxic chemotherapy, thereby
exerting a tumor-suppressor function.
for anticancer strategies that inhibit NF-κB signaling. Two recent publications in Genes &
Development provide evidence that, in contexts where prosurvival signals derive from other
oncogenes, NF-κB activity instead enhances sensitivity to cytotoxic chemotherapy, thereby
exerting a tumor-suppressor function.
Constitutive activation of NF-κB signaling can promote oncogenesis, providing a rationale for anticancer strategies that inhibit NF-κB signaling. Two recent publications in Genes & Development provide evidence that, in contexts where prosurvival signals derive from other oncogenes, NF-κB activity instead enhances sensitivity to cytotoxic chemotherapy, thereby exerting a tumor-suppressor function.
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