Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

G Thurston, C Suri, K Smith, J McClain, TN Sato… - Science, 1999 - science.org
G Thurston, C Suri, K Smith, J McClain, TN Sato, GD Yancopoulos, DM McDonald
Science, 1999science.org
Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell–
specific growth factors. Direct comparison of transgenic mice overexpressing these factors in
the skin revealed that the VEGF-induced blood vessels were leaky, whereas those induced
by Ang1 were nonleaky. Moreover, vessels in Ang1-overexpressing mice were resistant to
leaks caused by inflammatory agents. Coexpression of Ang1 and VEGF had an additive
effect on angiogenesis but resulted in leakage-resistant vessels typical of Ang1. Ang1 …
Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell–specific growth factors. Direct comparison of transgenic mice overexpressing these factors in the skin revealed that the VEGF-induced blood vessels were leaky, whereas those induced by Ang1 were nonleaky. Moreover, vessels in Ang1-overexpressing mice were resistant to leaks caused by inflammatory agents. Coexpression of Ang1 and VEGF had an additive effect on angiogenesis but resulted in leakage-resistant vessels typical of Ang1. Ang1 therefore may be useful for reducing microvascular leakage in diseases in which the leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels.
AAAS