NLRs, inflammasomes, and viral infection
SR Jacobs, B Damania - Journal of leukocyte biology, 2012 - academic.oup.com
SR Jacobs, B Damania
Journal of leukocyte biology, 2012•academic.oup.comReview on the interplay between NLR proteins, and RNA and DNA viruses. NLR proteins
are innate immune sensors that respond to microbial infection. Upon pathogen infection,
some NLR proteins form large complexes, called inflammasomes, which activate caspase-1
and induce the production of active IL-1β and IL-18. Activation of inflammasomes can also
lead to an inflammatory cell death program, named pyroptosis. In this review, we will discuss
the role of various NLR proteins in sensing different viral infections, as well as the strategies …
are innate immune sensors that respond to microbial infection. Upon pathogen infection,
some NLR proteins form large complexes, called inflammasomes, which activate caspase-1
and induce the production of active IL-1β and IL-18. Activation of inflammasomes can also
lead to an inflammatory cell death program, named pyroptosis. In this review, we will discuss
the role of various NLR proteins in sensing different viral infections, as well as the strategies …
Abstract
Review on the interplay between NLR proteins, and RNA and DNA viruses.
NLR proteins are innate immune sensors that respond to microbial infection. Upon pathogen infection, some NLR proteins form large complexes, called inflammasomes, which activate caspase-1 and induce the production of active IL-1β and IL-18. Activation of inflammasomes can also lead to an inflammatory cell death program, named pyroptosis. In this review, we will discuss the role of various NLR proteins in sensing different viral infections, as well as the strategies used by several RNA and DNA viruses to counteract the antiviral effects of NLR-dependent inflammasomes.
Oxford University Press