[HTML][HTML] Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus
OB Spiller, DJ Blackbourn, L Mark, DG Proctor… - Journal of Biological …, 2003 - ASBMB
Kaposi's sarcoma-associated herpesvirus (KSHV) is closely associated with Kaposi's
sarcoma and certain B-cell lymphomas. The fourth open reading frame of the KSHV genome
encodes a protein (KSHV complement control protein (KCP, previously termed ORF4))
predicted to have complement-regulating activity. Here, we show that soluble KCP strongly
enhanced the decay of classical C3-convertase but not the alternative pathway C3-
convertase, when compared with the host complement regulators: factor H, C4b-binding …
sarcoma and certain B-cell lymphomas. The fourth open reading frame of the KSHV genome
encodes a protein (KSHV complement control protein (KCP, previously termed ORF4))
predicted to have complement-regulating activity. Here, we show that soluble KCP strongly
enhanced the decay of classical C3-convertase but not the alternative pathway C3-
convertase, when compared with the host complement regulators: factor H, C4b-binding …