[HTML][HTML] Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos· c-Jun activator protein-1 complex that causes apoptosis in macrophages
M Asim, R Chaturvedi, S Hoge, ND Lewis… - Journal of biological …, 2010 - ASBMB
Macrophages are essential components of innate immunity, and apoptosis of these cells
impairs mucosal defense to microbes. Helicobacter pylori is a gastric pathogen that infects
half of the world population and causes peptic ulcer disease and gastric cancer. The host
inflammatory response fails to eradicate the organism. We have reported that H. pylori
induces apoptosis of macrophages by generation of polyamines from ornithine
decarboxylase (ODC), which is dependent on c-Myc as a transcriptional enhancer. We have …
impairs mucosal defense to microbes. Helicobacter pylori is a gastric pathogen that infects
half of the world population and causes peptic ulcer disease and gastric cancer. The host
inflammatory response fails to eradicate the organism. We have reported that H. pylori
induces apoptosis of macrophages by generation of polyamines from ornithine
decarboxylase (ODC), which is dependent on c-Myc as a transcriptional enhancer. We have …