The epidermal growth factor receptor pathway: a model for targeted therapy

M Scaltriti, J Baselga - Clinical cancer research, 2006 - AACR
M Scaltriti, J Baselga
Clinical cancer research, 2006AACR
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is
frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as
a target for cancer therapy, and after 2 decades of intensive research, there are several anti-
EGFR agents available in the clinic. Recent advances in our understanding in the
mechanisms of receptor activation and function, discovery of primary and secondary EGFR
somatic mutations, as well as a new generation of anti-EGFR agents provide new leads on …
Abstract
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as a target for cancer therapy, and after 2 decades of intensive research, there are several anti-EGFR agents available in the clinic. Recent advances in our understanding in the mechanisms of receptor activation and function, discovery of primary and secondary EGFR somatic mutations, as well as a new generation of anti-EGFR agents provide new leads on the clinical targeting of this receptor and may serve as a model for strategies aimed at targeting other receptors.
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