[HTML][HTML] Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling
Signaling through mammalian target of rapamycin complex 1 (mTORC1) is stimulated by
amino acids and insulin. Insulin inactivates TSC1/2, the GTPase-activator complex for Rheb,
and Rheb· GTP activates mTORC1. It is not clear how amino acids regulate mTORC1.
FKBP38 (immunophilin FK506-binding protein, 38 kDa), was recently reported to exert a
negative effect on mTORC1 function that is relieved by its binding to Rheb· GTP. We confirm
that Rheb binds wild type FKBP38, but inactive Rheb mutants showed contrasting abilities to …
amino acids and insulin. Insulin inactivates TSC1/2, the GTPase-activator complex for Rheb,
and Rheb· GTP activates mTORC1. It is not clear how amino acids regulate mTORC1.
FKBP38 (immunophilin FK506-binding protein, 38 kDa), was recently reported to exert a
negative effect on mTORC1 function that is relieved by its binding to Rheb· GTP. We confirm
that Rheb binds wild type FKBP38, but inactive Rheb mutants showed contrasting abilities to …