Pi3k-pkb/akt pathway
BA Hemmings, DF Restuccia - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
BA Hemmings, DF Restuccia
Cold Spring Harbor perspectives in biology, 2012•cshperspectives.cshlp.orgPI3K-PKB/Akt Pathway Page 1 PI3K-PKB/Akt Pathway Brian A. Hemmings and David F. Restuccia
Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland Correspondence:
david.restuccia@fmi.ch Identification of the phosphoinositide-3-kinase–protein kinase B/Akt
(PI3K-PKB/Akt) pathway and activating receptor tyrosine kinases (RTKs) began in earnest in the
early 1980s through vigorous attempts to characterize insulin receptor signaling (for review, see
Alessi 2001; Brazil and Hemmings 2001). These humble beginnings led to the identification of …
Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland Correspondence:
david.restuccia@fmi.ch Identification of the phosphoinositide-3-kinase–protein kinase B/Akt
(PI3K-PKB/Akt) pathway and activating receptor tyrosine kinases (RTKs) began in earnest in the
early 1980s through vigorous attempts to characterize insulin receptor signaling (for review, see
Alessi 2001; Brazil and Hemmings 2001). These humble beginnings led to the identification of …
Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled by a multi-step process that involves phosphoinositide-3-kinase (PI3K).
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