Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particles
HS Kruth - Current opinion in lipidology, 2011 - journals.lww.com
HS Kruth
Current opinion in lipidology, 2011•journals.lww.comContrary to what has been believed previously, macrophages can take up large amounts of
native unmodified LDL by receptor-independent, fluid-phase pinocytosis converting these
macrophages into foam cells. Thus, targeting macrophage fluid-phase pinocytosis should be
considered when investigating strategies to limit macrophage cholesterol accumulation in
atherosclerotic plaques.
native unmodified LDL by receptor-independent, fluid-phase pinocytosis converting these
macrophages into foam cells. Thus, targeting macrophage fluid-phase pinocytosis should be
considered when investigating strategies to limit macrophage cholesterol accumulation in
atherosclerotic plaques.
Summary
Contrary to what has been believed previously, macrophages can take up large amounts of native unmodified LDL by receptor-independent, fluid-phase pinocytosis converting these macrophages into foam cells. Thus, targeting macrophage fluid-phase pinocytosis should be considered when investigating strategies to limit macrophage cholesterol accumulation in atherosclerotic plaques.
Lippincott Williams & Wilkins