TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth
S Patan - Microvascular research, 1998 - Elsevier
As shown previously, TIE1 and TIE2 receptor tyrosine kinases are specifically expressed in
endothelial cells during embryonic angiogenesis. A detailed analysis of the vascular
malformations of homozygous mice for a targeting mutation of both receptors was performed
at the histological and cellular level. The data demonstrate that the TIE1 and TIE2 receptor
inversely and concomitantly mediate interactions between endothelial cells with their
extracellular matrix and with surrounding mesenchymal cells. These interactions are …
endothelial cells during embryonic angiogenesis. A detailed analysis of the vascular
malformations of homozygous mice for a targeting mutation of both receptors was performed
at the histological and cellular level. The data demonstrate that the TIE1 and TIE2 receptor
inversely and concomitantly mediate interactions between endothelial cells with their
extracellular matrix and with surrounding mesenchymal cells. These interactions are …