Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis
T Stiehl, K Thamm, J Kaufmann, U Schaeper… - Critical care …, 2014 - journals.lww.com
Objective: Angiopoietin-2, a protein secreted by stimulated endothelium and an antagonist
of the endothelium-stabilizing receptor Tie2, contributes to the pathophysiology of septic
multiple organ dysfunction. We tested the therapeutic potential of a pulmonary-endothelium-
specific RNA interference–based angiopoietin-2 targeting strategy in sepsis. Design:
Laboratory and animal research. Settings: Research laboratories of the Medical School
Hannover, Department of Nephrology and Hypertension, Hannover and Silence …
of the endothelium-stabilizing receptor Tie2, contributes to the pathophysiology of septic
multiple organ dysfunction. We tested the therapeutic potential of a pulmonary-endothelium-
specific RNA interference–based angiopoietin-2 targeting strategy in sepsis. Design:
Laboratory and animal research. Settings: Research laboratories of the Medical School
Hannover, Department of Nephrology and Hypertension, Hannover and Silence …