[HTML][HTML] A comparative analysis of FISH, RT-PCR, PCR, and immunohistochemistry for the diagnosis of mantle cell lymphomas
MA Belaud-Rotureau, M Parrens, P Dubus… - Modern Pathology, 2002 - Elsevier
Mantle cell lymphoma (MCL) diagnosis first relies on morphology and phenotype that may
overlap with other B-cell lymphomas. Therefore, the demonstration of t (11; 14)(q13; q32),
the cytogenetic hallmark of MCL, is considered of diagnostic value. By studying a series of
35 MCL with characteristic morphology and phenotype (CD5+, CD10−, CD20+, CD23−), we
have evaluated the applicability and the sensitivity of interphase fluorescence in situ
hybridization (FISH) for t (11; 14) detection and other techniques:(1) polymerase chain …
overlap with other B-cell lymphomas. Therefore, the demonstration of t (11; 14)(q13; q32),
the cytogenetic hallmark of MCL, is considered of diagnostic value. By studying a series of
35 MCL with characteristic morphology and phenotype (CD5+, CD10−, CD20+, CD23−), we
have evaluated the applicability and the sensitivity of interphase fluorescence in situ
hybridization (FISH) for t (11; 14) detection and other techniques:(1) polymerase chain …