Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL
M Sattler, R Salgia - Cytokine & growth factor reviews, 1997 - Elsevier
BCR/ABL is a human chimeric oncogene that causes chronic myelogenous leukemia (CML).
The BCR/ABL oncogene is generated from the Philadelphia chromosome (Ph) translocation,
t (9; 22)(q34; q11), and creates a constitutively active tyrosine kinase. There is clonal
expansion of hematopoietic stem cells of several different lineages in CML. CML patients in
stable phase usually have high white blood counts and immature cells of granuloctyic
lineages. Stable phase CML evolves to a more aggressive phase typically within 3.5–5 …
The BCR/ABL oncogene is generated from the Philadelphia chromosome (Ph) translocation,
t (9; 22)(q34; q11), and creates a constitutively active tyrosine kinase. There is clonal
expansion of hematopoietic stem cells of several different lineages in CML. CML patients in
stable phase usually have high white blood counts and immature cells of granuloctyic
lineages. Stable phase CML evolves to a more aggressive phase typically within 3.5–5 …