Growth factors, insulin signaling, and nutrients are important regulators of β-cell mass and
function. The events linking these signals to the regulation of β-cell mass are not completely
understood. The mTOR pathway integrates signals from growth factors and nutrients. Here,
we evaluated the role of the mTOR/raptor (mTORC1) signaling in proliferative conditions
induced by controlled activation of Akt signaling. These experiments show that the mTORC1
is a major regulator of β-cell cycle progression by modulation of cyclin D2, D3, and Cdk4 …