[CITATION][C] Effects of Different Regimens of Dietary Restriction on the Age‐Related Decline in Insulin Secretory Response of Isolated Rat Pancreatic Isletsa

E Bergamini, M Bombara, V Fierabracci… - Annals of the New …, 1991 - Wiley Online Library
E Bergamini, M Bombara, V Fierabracci, P Masiello, M Novelli
Annals of the New York Academy of Sciences, 1991Wiley Online Library
It is well known that the process of aging results in a progressive deterioration in most
endocrine functions. With regard to the pancreas, there is evidence that the ability of the rat
to maintain insulin secretory function decreases with increasing age, since islets from old
rats are larger and contain more insulin than islets from young rats, but do not release in
uitro insulin as rapidly as do these latter islets. In this report, we show that the onset of the
functional decline of beta cells can be timed by the age of 6-9 months. The process is likely …
It is well known that the process of aging results in a progressive deterioration in most endocrine functions. With regard to the pancreas, there is evidence that the ability of the rat to maintain insulin secretory function decreases with increasing age, since islets from old rats are larger and contain more insulin than islets from young rats, but do not release in uitro insulin as rapidly as do these latter islets.
In this report, we show that the onset of the functional decline of beta cells can be timed by the age of 6-9 months. The process is likely to be related to rat longevity, since it can be modulated by dietary re~ triction,~ the most effective antiaging strategy tested in
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