[HTML][HTML] Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
ME Cockman, N Masson, DR Mole, P Jaakkola… - Journal of Biological …, 2000 - ASBMB
The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in
cellular responses to oxygen availability, being required for the oxygen-dependent
proteolysis of α subunits of hypoxia inducible factor-1 (HIF). Mutations in VHL cause a
hereditary cancer syndrome associated with dysregulated angiogenesis, and up-regulation
of hypoxia inducible genes. Here we investigate the mechanisms underlying these
processes and show that extracts from VHL-deficient renal carcinoma cells have a defect in …
cellular responses to oxygen availability, being required for the oxygen-dependent
proteolysis of α subunits of hypoxia inducible factor-1 (HIF). Mutations in VHL cause a
hereditary cancer syndrome associated with dysregulated angiogenesis, and up-regulation
of hypoxia inducible genes. Here we investigate the mechanisms underlying these
processes and show that extracts from VHL-deficient renal carcinoma cells have a defect in …