[HTML][HTML] Fatty liver in familial hypobetalipoproteinemia: roles of the APOB defects, intra-abdominal adipose tissue, and insulin sensitivity
T Tanoli, P Yue, D Yablonskiy, G Schonfeld - Journal of lipid research, 2004 - ASBMB
Fatty liver is frequent in the apolipoprotein B (apoB)-defective genetic form of familial
hypobetalipoproteinemia (FHBL), but interindividual variability in liver fat is large. To explain
this, we assessed the roles of metabolic factors in 32 affected family members with apoB-
defective FHBL and 33 related and unrelated normolipidemic controls matched for age, sex,
and indices of adiposity. Two hour, 75 g oral glucose tests, with measurements of plasma
glucose and insulin levels, body mass index, and waist-hip ratios were obtained. Abdominal …
hypobetalipoproteinemia (FHBL), but interindividual variability in liver fat is large. To explain
this, we assessed the roles of metabolic factors in 32 affected family members with apoB-
defective FHBL and 33 related and unrelated normolipidemic controls matched for age, sex,
and indices of adiposity. Two hour, 75 g oral glucose tests, with measurements of plasma
glucose and insulin levels, body mass index, and waist-hip ratios were obtained. Abdominal …