[HTML][HTML] The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism

HN Ginsberg, EA Fisher - Journal of lipid research, 2009 - ASBMB
Apolipoprotein B (apoB) is the essential protein required for the assembly and secretion of
chylomicrons from the small intestine and VLDLs from the liver. These lipoproteins, as well
as their remnants and LDL, play key roles in the transport of dietary and endogenously
synthesized lipids throughout the body. However, they can be involved in the initiation of
atherosclerotic lesions in the vessel wall. Therefore, it is not surprising that the assembly of
apoB-containing lipoproteins in the small intestine and liver is a highly regulated process. In …