T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication
LF Liu, CC Liu, BM Alberts - Nature, 1979 - nature.com
LF Liu, CC Liu, BM Alberts
Nature, 1979•nature.comAbstract A novel ATP-dependent DNA topoisomerase which makes reversible double-strand
breaks in the DNA double helix has been purified to near homogeneity from T4
bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is
essential for initiating T4 DNA replication forks in vivo.
breaks in the DNA double helix has been purified to near homogeneity from T4
bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is
essential for initiating T4 DNA replication forks in vivo.
Abstract
A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.
nature.com